Athena is one of the Spirit Deities in Ryse: Son of Rome. She first appears after Marius Titus loses his way, telling him where to go while a large group of barbarians come from the other way. She then appears after Marius is defeated by Glott, telling him to rise and guides him to the location of his shield and sword. After York falls and Marius is thrown into the river, she saves his life by throwing a knife into the water. She appears again when Marius revisits Rome, telling him to kill Nero, and warns him before the latter stabs him with a knife. Finally, she appears together with Aquilo, before Marius' death.